In this multicentre, prospective, observational, cohort study of 60 individuals with lung injury related to e-cigarettes or vaping observed in Intermountain Healthcare, an integrated health system based in Utah, USA, between June 27 and Oct 4, 2019, experts determined the clinical presentation, treatment, and short-term outcomes of lung injury related to e-cigarettes or vaping. It was discovered that lung injury correlated with e-cigarettes or vaping is a rising illness related to severe lung injury and constitutional and gastrointestinal symptoms. In individuals who were treated with antibiotics and steroids, heightened awareness resulted in the recognition of a broad spectrum of severity of illness. Irrespective of the betterment, at short-term follow-up, residual abnormalities had many individuals. Nevertheless, lung injury-related to e-cigarettes or vaping continues to be a clinical diagnosis with symptoms that overlap infectious and other lung diseases. Moreover, as work persists to be in knowing the cause or causes, optimal therapy, and long-term outcomes of these individuals, sustaining a high index of the doubt for this disease is significant.